Santhini Pulikkal Veettil

ACADEMIC BACKGROUND

• Ph.D. in Chemical Sciences (April 2018), research work carried out at CSIR–NIIST, Thiruvananthapuram, under the combined guidance of Dr. K. V. Radhakrishnan and Dr. R. Luxmi Varma, Degree awarded from Academy of Scientific and Innovative Research (AcSIR), New Delhi.
• M Sc. in Chemistry (2011), Kannur University, Kerala, India with university 1^st rank.
• B Sc. in Chemistry specialized in Polymer Chemistry (Main) with university 1^st rank.

RESEARCH EXPERIENCE

• DBT-Ramalingaswami Re-entry Fellow (September 2022-September 2025): Dept. of Applied Chemistry, Cochin University of Science and Technology, Kerala (Organic and Natural product Chemistry)
• SERB-National Postdoctoral Fellow (February 2022-September 2022): Dept. of Applied Chemistry, Cochin University of Science and Technology, Kerala with Prof. N. Manoj (Fluorescent organic molecules)
• Research Associate (October 2021-February 2022): National Centre for Aquatic animal Health, CUSAT with Prof. Sajeevan T. P (Marine natural products)
• PDM Postdoctoral fellow (2018- 2021): University of Leuven (KU Leuven), Belgium. Research supervisor; Prof. Dr. Wim Dehaen (Heterocyclic and Medicinal Chemistry)
• Research Fellow: CSIR-NIIST, Thiruvannathapuram, India, 2013-2018
• Project Assistant: CSIR-NIIST, Thiruvannathapuram, India, 2012

AWARDS AND FELLOWSHIPS

     1.ANRF-Early Career Research Grant by ANRF, Govt. of India-2024

     2.DBT-Ramalingaswami Re-entry Fellowship-Department of Biotechnology, Govt. of India-2021

3. SERB-National Postdoctoral Fellowship

4. PDM-Postdoctoral fellowship– 2018 at KU Leuven, Belgium with Prof. Wim Dehaen,

5. Junior Research Fellowship (JRF) and National Eligibility Test (NET), Council of Scientific and Industrial Research – 2011
6. DST–Inspire–Junior Research Fellowship (JRF), DST, India – 2012 (not availed)
7. Graduate Aptitude Test in Engineering (GATE score: 98%) – 2012
8. 1^st rank from Kannur University, M.Sc. Chemistry – 2011
9. 1^st rank from Kannur University, B.Sc Polymer Chemistry – 2009
10. Best student of the college award by PTA, Nehru Arts and Science college, Kanhangad-2009

LIST OF PUBLICATIONS

• “Citrinin (CIT), a polyketide mycotoxin from a mangrove endophytic fungus Penicillium rubens EF 363 and its bioactive potential” MR Revathy, Anjali S Mohan, Dhanya Kesavan, M Dhaneesha, PV Santhini, Muralidharan Vanuopadath, Bipin G Nair, Remington X Poulin, TP Sajeevan, Rosamma Philip, Vegetos, 2025, 1, 1-10
• “Detection of antiviral moieties in the leaves of Rhizophora mucronata functional on the shrimp pathogen Penaeus stylirostris penstyldensovirus 1 (PstDVI)/IHHNV …’’ Ahna Ameer, Diya Dominic D V, Lakshmi Gopakumar, Francis Murray, Madiyan Saranya, Santhini P V, IS Bright Singh Aquaculture International 2024, 1-18
• “Development of polyethyleneimine cross-linked fucoidan nanoparticles as delivery systems for improved anticancer efficiency of cytarabine in breast adenocarcinoma cell lines’’ Deepa G , Santhini Pulikkal Veettil , Sivakumar, Anoop B Rojin J , Shibin S P, Jisha V S and Sajeevan T P  RSC Pharmaceutics 2024, 1, 305-316
• ‘Rhodium-Catalyzed Transannulation of 4, 5-Fused 1-Sulfonyl-1, 2, 3-triazoles with Nitriles. The Selective Formation of 1-Sulfonyl-4, 5-fused Imidazoles versus Secondary C–H Bond Migration’ VG Ilkin, T. V. Beryozkina, D. Willocx, P. S Silaichev, V. Santhini, W. Dehaen, V. A Bakulev, J. Org. Chem.2022, 87, 18, 12274.
• ‘Tandem Reaction of 4‐Halo‐1, 3‐Dicarbonyl Compounds with Alkynes towards 4‐Vinyl‐3 (2H)‐Furanones and 3 (2H)‐Furanone fused 2‐Pyridones’ K Omanakuttan, P.V. Santhini, S Shaludheen, S. Varughese, H. Hopf, J. John Asian Journal of Organic Chemistry, e202200410 (Corresponding author) DOI: 10.1002/ajoc.202200410– in Press.
• ‘An Efficient Magnesium Phyllosilicate‐Nano Palladium Hybrid Catalyst for the Selective Oxidation of Organosilanes’ V. Santhini, G. Das, J. A. S Kumar, B. Vedhanarayanan, V. K Praveen, J. John Chemistry Select 2022, 7 (27), e202200548.
• ‘The Synthesis of Five-Membered N-Heterocycles by Cycloaddition of Nitroalkenes with (In) Organic Azides and Other 1, 3-Dipoles’ V. Santhini, Shandev P. P, Wim Dehaen, Synthesis 2021, DOI: 10.1055/a-1547-0196 (in Press).
• ‘A Multicomponent Approach toward Angularly Fused/Linear Bitriazoles: A Cascade Cornforth Rearrangement and Triazolization’: V. Santhini, Shandev P. P, Max, V. H., Wim Dehaen, The journal of organic chemistry, 2021, 86, 4346.
• ‘Cancer cell death strategies by targeting Bcl-2’s BH4 domain’ I. de Ridder, M. Kerkhofs, Santhini P. V., W. Dehaen , G. Bultynck., BBA – Mol Cell Res, 2021, 1868, 118983. DOI: 1016/j.bbamcr.2021.118983.
• The Three-Component Synthesis of 4-Sulfonyl-1,2,3-triazoles via a Sequential Aerobic Copper-Catalyzed Sulfonylation and Dimroth Cyclization , Max, V. H., V. Santhini, Wim Dehaen molecules, 2021, 26,581.
• ‘BOPAHY-: A doubly chelated highly fluorescent pyrrole-acyl hydrazone –BF2 Chromophore’: P. Shandev, F. de Jong, K. Veys, J. Huang, P. V. Santhini, D. Verhaeghe, L. V. Meervelt, D.l Escudero, M. V. der Auweraer and W. Dehaen, Chem. Commun., 2020, 56, 5791.
• ‘1,2,3-Triazolium Macrocycles in Supramolecular Chemistry’: Mastaneh Safarnejad Shad, Santhini P. V. Wim Dehaen, Beilstein J. Org. Chem. 2019, 15, 2142–2155.
• Indolo[3,2-b]indole donor-based D–π–A dyes for DSCs: investigating the role of π-spacers towards recombination; V. Santhini, Jayadev V., Sourav, C. Pradhan, S. Lingamoorthy, Nitha P. R., Chaithanya M. V., Rakesh K. Mishra, Narayanan Unni K. N., Jubi John, Suraj Soman, New J. Chem., 2019, 43, 862.
• ‘Rh(III)-Catalyzed C-H Activation-Desymmetrization of Diazabicycles with Aryl Ketones: A Facile Synthesis of Functionalized Cyclopentenes’; V. Santhini, G. Goplan, A. S. Smrithy, K. V. Radha-krishnan. Synlett, 2018, 29, 2023.
• ‘Accessing Highly Functionalized Cyclopentanoids via Cascade Palladation Approach: Unprecedented Benzylic C-H Activation towards Cyclopentenoindanes’; V. Santhini, A. S. Smrithy, C. P. Irfana Jesin, S. Varughese, J. John, K. V. Radhakrishnan. Chem. Commun., 2018, 54, 2982.
• ‘Pd-Catalyzed Oxidative Annulation of Enamides with Diazabicyclic Olefins: A Rapid Access to Cyclopentene Fused 2-Pyrrolines’; V. Santhini, G.Nimisha,  J. John, E. Suresh, R. Luxmi Varma, K. V. Radhakrishnan, Chem. Commun., 2017, 53, 1848.
• ‘Lewis Acid Catalyzed Three Component (3+2) Cycloaddition Reaction Using Pentafulvene as 2π Component: An Easy Way to Construct Pentaleno (1, 2-b)indoles’; V. Santhini , S. Sarath Chand, J.John, R. Luxmi Varma, F. Jaroschik, K. V. Radhakrishnan, Synlett, 2017, 28, 951.
• ‘Heteroannulation of 3‑Nitroindoles and 3‑Nitrobenzo[b]thiophenes: A Multicomponent Approach toward Pyrrole-Fused Heterocycles’; V. Santhini, S. A. Babu, R. K. Akhil, E. Suresh, J. John, Org. Lett., 2017, 19, 2458.
• ‘One-Pot Oxidation Approach toward Indole-fused Heteroacenes’; V. Santhini, R. A. Krishnan, S. A. Babu, B. S. Simethy, G. Das, V. K. Praveen, S. Varughese, J. John, J. Org. Chem.,2017, 82, 10537.
• ‘Lewis Acid Catalysed Unprecedented Regioselective Hydroheteroarylation of Pentafulvenes’; S. S. Chand, G.Gopalan, V. Santhini, P. Preethanuj, J. John, D.Harakat, Jean-Luc Vasse, Florian Jaroschik, K. V. Radhakrishnan, Org. Lett.,2016, 18, 964.
• ‘Trapping the Lewis acid generated transient species from pentafulvene derived diazanorbornenes with ortho-functionalized aryl iodides and aliphatic alcohols’; S. S. Chand, S. Saranya, P. Preethanuj, B. P. Dhanya, E. Jijy, P. Prakash, B. S. Sasidhar, J. Szymoniak, V. Santhini, K. V. Radhakrishnan, Org. Biomol. Chem., 2014, 12, 3045.
• ‘Rhodium(III)-Catalyzed C–H Activation of Phenylazoles toward C–N Bond Cleavage of Diazabicyclic Olefins: A Facile Access to Mono- and Biscyclopentenyl-Functionalized Aza-Heteroaromatics’; P. Prakash, P. S. Aparna, E. Jijy, V. Santhini, S. Varughese, K. V. Radhakrishnan, Synlett, 2014, 25, 275.

List of Patents : 1

• V. Santhini, W. Dehaen, L. Ponet, B. Cammue., Novel systemic resistance-inducing agents for plants, Provisional Patent Application, 2024.

List of Projects : 2